PROJECT

Anti-bacteriophage defense systems

Bacteriophages can kill bacterial cells, and have been used as an alternative to antibiotic therapies to treat bacterial diseases in humans. Recently, it was discovered that, bacteria also have immune systems, to protect them against their viruses. These nti-bacteriophage defence systems are poorly understood. We study their structures, to understand them better.
PROJECT

Bacteriophages and contractile injection systems

Bacteriophages are the viruses of bacteria, and are the most abundant biological units on the planet. Our research is focused on elucidating the structural details of how bacteriophages, and other contractile injection systems, pierce cell membranes to deliver their payloads.
PROJECT

Bacterial flagellar motor

Many bacteria use the flagellum for locomotion and chemotaxis, whereas flagella are considered a virulence factor in many human pathogens. Its bidirectional rotation is driven by a membrane-embedded motor, we study the structure and function of the bacterial flagellar motor.

News

Our latest paper reveals the structure of Vibrio sodium-dependent stator units (PomAB). The electrostatic potential map uncovers sodium binding sites, which together with functional experiments and molecular dynamics simulations, reveal a mechanism for ion translocation and selectivity.

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Nicholas M. I. Taylor

Associate Professor
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