Preprints


Role of N-glycosylation as a determinant of ATG9A conformations and activity

Lambrughi, M., Utichi, M., Borg, C.B., Marjault, H-B.,  Echeverría, S.E., Maeda, K., Taylor, N.M.I., Fadda, E., Jäättelä, M., Papaleo, E., 2025

LINK | PDF

Towards a complete phage tail fiber structure atlas
Klien-Sousa, V., Roa-Eguiara, A., Kielkopf, C.S, Sofos, N., Taylor, N.M.I., 2024.

LINK | PDF | CODE

N-terminal toxin signal peptides efficiently load therapeutics into a natural nano-injection system
Steiner-Rebrova, E.M., Ejaz, R.N., Kielkopf, C.S., Ruiz, M.P., Marín-Arraiza, L., Hendriks, I.A., Nissen, J.N., Pozdnyakova, I., Pape, T., Regaiolo, A., Götz, K., Heermann, R., Rasmussen, S., Nielsen, M.L., Taylor, N.M.I., 2023.

LINK | PDF

2025


Structure and mechanism of Zorya anti-phage defense system
Hu, H., Popp, P.F., Hughes, T.C.D.,  Roa-Eguiara, A., Rutbeek, N.R., Martin, F.J.O., Hendriks, I.A., Payne, L.J., Yan, Y., Humolli, D., Klein-Sousa, V., Songailiene I., Wang, Y., Nielsen, M.L., Berry, R.M., Erhardt, M., Jackson, S.A., Taylor, N.M.I., Nature 2025.

LINK | PDF

2024


T6SS-associated Rhs toxin-encapsulating shells: Structural and bioinformatical insights into bacterial weaponry and self-protection

Kielkopf, C.S., Shneider, M.M., Leiman, P.G., Taylor, N.M.I., 2024, Structure, 32, 12, 2375 – 2389.e5

LINK | PDF

Ion-driven rotary membrane motors: From structure to function
Martin, F.J.O., Santiveri, M., Hu, H., Taylor, N.M.I., Curr. Opin. Struct. Biol. 2024, 88:102884

LINK | PDF

Diversity and phage sensitivity to phages of porcine enterotoxigenic Escherichia coli
Gambino, M.,  Kushwaha, S.K., Wu, Y., van Haastrecht, P., Klein-Sousa, V., Lutz, V.T., Bejaoui, S., Jensen, C.M.C., Bojer, M.S., Song, W., Xiao, M., Taylor, N.M.I., Nobrega, F.L., Brøndsted, L., 2024. Appl. Environ. Microbiol. 90:e00807-24.

LINK | PDF

Protocol for genomic recombineering in Yersinia ruckeri using CRISPR Cas12a coupled with the λ Red system
Ejaz R.N., Taylor, N.M.I., Steiner-Rebrova, E.M., 2024. STAR Protocols 5, 2, 103014.

LINK | PDF

Agtrevirus phage AV101 recognizes four different O-antigens infecting diverse E. coli
Sørensen, A.N., Kalmár, D., Lutz, V.T., Klein-Sousa, V., Taylor, N.M.I., Sørensen, M.C., Brøndsted, L., 2024. microLife 5, uqad047.

LINK | PDF

2023


Depicting protein structures as schematics
Markert, J., Luger, K., Lee, H., Hu, H., Taylor, N.M.I., Fernandez-Martinez, J., Rout, M., Alder, N., 2023. Trends Biochem. Sci. 48, 307–310.

LINK | PDF

Ion selectivity and rotor coupling of the Vibrio flagellar sodium-driven stator unit
Hu, H., Popp, P.F., Santiveri, M., Roa-Eguiara, A., Yan, Y., Martin, F.J.O., Liu, Z., Wadhwa, N., Wang, Y., Erhardt, M., Taylor, N.M.I., 2023. I Nat. Commun. 14, 4411.

LINK | PDF

Structural and mechanistic basis of substrate transport by the multidrug transporter MRP4
Bloch, M., Raj, I., Pape, T., Taylor, N.M.I., 2023. Structure 31, 1407-1418.e6.

LINK | PDF

2022


Cryo-EM structure of native human thyroglobulin
Adaixo, R., Steiner, E.M., Righetto, R.D., Schmidt, A., Stahlberg, H., Taylor, N.M.I., 2022. Nat. Commun. 13, 61.

LINK | PDF

Structural basis of torque generation in the bi-directional bacterial flagellar motor
Hu, H., Santiveri, M., Wadhwa, N., Berg, H.C., Erhardt, M., Taylor, N.M.I., 2022. Trends Biochem. Sci. 47, 160–172.

LINK | PDF

Expression, purification and characterization of human proton-coupled oligopeptide transporter 1 hPEPT1
Rafiq, M., Ernst, H.A., Aduri, N.G., Prabhala, B.K., Tufail, S., Rahman, M., Bloch, M.B., Mirza, N., Taylor, N.M.I., Boesen, T., Gajhede, M., Mirza, O., 2022. Protein Expr. Purif. 190, 105990.

LINK | PDF

A new class of biological ion-driven rotary molecular motors with 5:2 symmetry
Rieu, M., Krutyholowa, R., Taylor, N.M.I., Berry, R.M., 2022. Front. Microbiol. 13.

LINK | PDF

2021


Tail Structure and Dynamics

Bhatt, S., Leiman, P.G., Taylor, N.M.I., 2021. in
Bamford, D.H., Zuckerman, M. (Eds.), Encyclopedia of Virology (Fourth Edition). Academic Press, Oxford, pp. 186–193.

LINKPDF

Structural basis for recognition of bacterial cell wall teichoic acid by pseudo-symmetric SH3b-like repeats of a viral peptidoglycan hydrolase
Shen, Y., Kalograiaki, I., Prunotto, A., Dunne, M., Boulos, S., I. Taylor, N.M., T. Sumrall, E., R. Eugster, M., Martin, R., Julian-Rodero, A., Gerber, B., G. Leiman, P., Menéndez, M., Dal Peraro, M., Javier Cañada, F., J. Loessner, M., 2021. Chem. Sci. 12, 576–589.

LINK | PDF

2020


Membrane Protein Cryo-EM: Cryo-Grid Optimization and Data Collection with Protein in Detergent
Bloch, M., Santiveri, M., Taylor, N.M.I., 2020. in: Perez, C., Maier, T. (Eds.), Expression, Purification, and Structural Biology of Membrane Proteins, Methods in Molecular Biology. Springer US, New York, NY, pp. 227–244.

LINK | PDF

The crystal structure of human XPG, the xeroderma pigmentosum group G endonuclease, provides insight into nucleotide excision DNA repair
González-Corrochano, R., Ruiz, F.M., Taylor, N.M.I., Huecas, S., Drakulic, S., Spínola-Amilibia, M., Fernández-Tornero, C., 2020. Nucleic Acids Res. 48, 9943–9958.

LINKPDF

FAM111 protease activity undermines cellular fitness and is amplified by gain‐of‐function mutations in human disease
Hoffmann, S., Pentakota, S., Mund, A., Haahr, P., Coscia, F., Gallo, M., Mann, M., Taylor, N.M., Mailand, N., 2020. EMBO Rep. 21, e50662.

LINK | PDF

Editorial overview: Virus structure and expression
Taylor, N.M.I., Leiman, P.G., 2020. Curr. Opin. Virol., 45. Virus structure & Expression (Dec 2020) 45, iii–v.

LINK | PDF

Structure and Function of Stator Units of the Bacterial Flagellar Motor
Santiveri, M., Roa-Eguiara, A., Kühne, C., Wadhwa, N., Hu, H., Berg, H.C., Erhardt, M., Taylor, N.M.I., 2020. Cell 183, 244-257.e16.

LINK | PDF

2019


Structure and Function of the Branched Receptor-Binding Complex of Bacteriophage CBA120
Plattner, M., Shneider, M.M., Arbatsky, N.P., Shashkov, A.S., Chizhov, A.O., Nazarov, S., Prokhorov, N.S., Taylor, N.M.I., Buth, S.A., Gambino, M., Gencay, Y.E., Brøndsted, L., Kutter, E.M., Knirel, Y.A., Leiman, P.G., 2019. J. Mol. Biol. 431, 3718–3739.

LINK | PDF

Structure and transformation of bacteriophage A511 baseplate and tail upon infection of Listeria cells
Guerrero‐Ferreira, R.C., Hupfeld, M., Nazarov, S., Taylor, N.M., Shneider, M.M., Obbineni, J.M., Loessner, M.J., Ishikawa, T., Klumpp, J., Leiman, P.G., 2019. EMBO J. 38, e99455.

LINK | PDF

2018


Contractile injection systems of bacteriophages and related systems.
Taylor, N.M.I., van Raaij, M.J., Leiman, P.G., 2018. Mol. Microbiol. 108, 6–15.

LINKPDF

Cryo-EM structure of alpha-synuclein fibrils. Guerrero-Ferreira, R.
Taylor, N.M., Mona, D., Ringler, P., Lauer, M.E., Riek, R., Britschgi, M., Stahlberg, H., 2018. eLife 7, e36402.

LINK | PDF

Structural basis of small-molecule inhibition of human multidrug transporter ABCG2.
Jackson, S.M., Manolaridis, I., Kowal, J., Zechner, M., Taylor, N.M.I., Bause, M., Bauer, S., Bartholomaeus, R., Bernhardt, G., Koenig, B., Buschauer, A., Stahlberg, H., Altmann, K.-H., Locher, K.P., 2018. Nat. Struct. Mol. Biol. 25, 333–340.

LINK | PDF

Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states.
Manolaridis, I., Jackson, S.M., Taylor, N.M.I., Kowal, J., Stahlberg, H., Locher, K.P., 2018. Nature 563, 426–430.

LINK | PDF

2017


Refined Cryo-EM Structure of the T4 Tail Tube: Exploring the Lowest Dose Limit.
Zheng, W., Wang, F., Taylor, N.M.I., Guerrero-Ferreira, R.C., Leiman, P.G., Egelman, E.H., 2017. Structure 25, 1436-1441.e2.

LINK | PDF

Structure of the human multidrug transporter ABCG2.
Taylor, N.M.I., Manolaridis, I., Jackson, S.M., Kowal, J., Stahlberg, H., Locher, K.P., 2017. Nature 546, 504–509.

LINK | LINK

2016


Structure of the T4 baseplate and its function in triggering sheath contraction.
Taylor, N.M.I., Prokhorov, N.S., Guerrero-Ferreira, R.C., Shneider, M.M., Browning, C., Goldie, K.N., Stahlberg, H., Leiman, P.G., 2016. Nature 533, 346–352.

LINK | PDF

2015


Architecture of TFIIIC and its role in RNA polymerase III pre-initiation complex assembly.
Male, G., von Appen, A., Glatt, S., Taylor, N.M.I., Cristovao, M., Groetsch, H., Beck, M., Müller, C.W., 2015. Nat. Commun. 6, 7387.

LINK | PDF

2014


Solving the RNA polymerase I structural puzzle.
Moreno-Morcillo, M., Taylor, N.M.I., Gruene, T., Legrand, P., Rashid, U.J., Ruiz, F.M., Steuerwald, U., Müller, C.W., Fernández-Tornero, C., 2014. Acta Crystallogr. D Biol. Crystallogr. 70, 2570–2582.

LINKPDF

2013


RNA polymerase III-specific general transcription factor IIIC contains a heterodimer resembling TFIIF Rap30/Rap74
Taylor, N. M. I., Baudin, F., von Scheven, G., Müller C.W., 2013, Nucleic Acids Research, 41, 19, 9183–9196.

LINK | PDF

Structural and Functional Characterization of a Phosphatase Domain within Yeast General Transcription Factor IIIC
Taylor, N.M.I., Glatt, S., Hennrich, M.L., Scheven, G. von, Grötsch, H., Fernández-Tornero, C., Rybin, V., Gavin, A.-C., Kolb, P., Müller, C.W., 2013. J. Biol. Chem. 288, 15110–15120.

LINK | PDF

2012


The Elongator subcomplex Elp456 is a hexameric RecA-like ATPase
Glatt, S., Létoquart, J., Faux, C., Taylor, N.M.I., Séraphin, B., Müller, C.W., 2012. Nat. Struct. Mol. Biol. 19, 314–320.

LINK | PDF